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KMID : 1007320150210020104
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Journal of the Korean Society of Menopause
2015 Volume.21 No. 2 p.104 ~ p.111
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Effects of Hormone Therapy on Serum Lipid Levels in Postmenopausal Korean Women
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Lee Jee-Yeon
Park Hyang-Gi
Seo Ji-Hyun
Lee Eun-Young
Lee Ji-Soo
Lee Dong-Yun
Choi Doo-Seok
Yoo Byung-Koo
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Abstract
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Objectives: This study was conducted to examine the effects of hormone therapy on serum lipid levels in postmenopausal Korean women.
Methods: This retrospective cohort study included 154 healthy postmenopausal Korean women. Seventy-nine women took oral estrogen (conjugated equine estrogen 0.625 mg/day or equivalent), and 75 applied estrogen transdermally using 0.1% 17ß-estradiol gel. Micronized progesterone (MP) was added to 40 women of oral group and 49 women in transdermal group. Serum levels of triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and lipoprotein (a) were measured before, 3 and 6 month after hormone therapy.
Results: At baseline, mean body mass index (BMI) were lower (22.76 vs. 23.74 kg/m2) and proportion of family history of cardiovascular disease (CVD) (61 vs. 39%) were higher in oral group. In oral group, LDL-C and lipoprotein(a) levels decreased, and triglyceride and HDL-C levels increased significantly after 3 and 6 months. There was no significant change in lipoprotein levels compared to the baseline in transdermal group. There were also no differences with additional MP. Changing pattern of HDL-C during 6 months was significantly different by the route of estrogen administration.
Conclusion: Oral estrogen therapy might be more beneficial than transdermal estrogen in terms of lipid in postmenopausal Korean women. The estrogen effects are not influenced by adding MP.
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KEYWORD
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Hormone replacement therapy, Lipids, Progesterone, Drug administration route
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